Quinolines and derivatives
Medchemexpress LLC ASP-9521 | 1126084-37-4 | 98.0% | 330.42 | 200 MG
ASP-9521 is a potent, selective, and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. It shows more than 100-fold selectivity for AKR1C3 over the isoform AKR1C2. This inhibitor suppresses AD-dependent PSA production and cell proliferation in LNCaP-AKR1C3 cells, and inhibits AD-induced intratumoural T production in CWR22R xenografts for up to 24 hours.
- Potent and selective AKR1C3 inhibitor
- Orally available
- High selectivity over AKR1C2
- Suppresses AD-dependent PSA production and cell proliferation
- Inhibits AD-induced intratumoural T production
- Inhibitory effect maintained for 24 hours
Medchemexpress LLC Nilotinib | 641571-10-0 | 99.9% | 529.52 | 200 MG
Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity, designed for research use. It exhibits significant inhibitory effects against Bcr-Abl and various other targets, making it suitable for studies on cell proliferation and cytotoxicity.
- Exhibits antiproliferative activity in A549 cells with an IC50 of 6.63 μM.
- Shows antiproliferative activity in BJ cells with an IC50 of 12.8 μM.
- Inhibits various BCR/ABL p210 mutants (GI50 0.004 μM to > 10 μM).
- Induces cytotoxicity against various BaF3 cell lines.
- Used in CCK-8 assays for IC50 assessment in liver cancer cell lines.
- Useful for observing anti-colony formation effects.
- Utilized for immunohistochemistry of primary tumors.
- Investigated for its direct effect on cytotoxic lymphocytes.
- Applied for cell cycle analysis.
Apexbio Technology LLC Iniparib (BSI-201) 160003-66-7 200mg
Iniparib (BSI-201) (CAS 160003-66-7) is a small-molecule inhibitor initially characterized as targeting poly(ADP-ribose) polymerase-1 (PARP1) It is designed to inhibit PARP1 by promoting oxidation of zinc finger motifs leading to zinc ejection and suppression of enzyme activity Iniparib exerts its biological activity primarily through metabolism into a C-nitroso intermediate which modifies cysteine residues in multiple proteins In cellular assays Iniparib demonstrates growth-inhibitory activity with reported IC50 values approximately ranging from 40 to 100 M in cancer cell lines Based on these pharmacological properties Iniparib holds research potential in oncology studies particularly in treatment-resistant and solid tumor models
Cambridge Isotope Laboratories CGA 580 / 3L carbon steel cylinder packless brass angle ea
CGA 580 / 3L carbon steel cylinder packless brass angle ea
eMolecules 88950-64-5 | 1-Aminocyclopropane-1-carboxylic acid, N-BOC protected | Apollo Scientific | MFCD00083257 | 201.222 | C9H15NO4 | 97.000 | CC(C)(C)OC(=O)NC1(CC1)C(O)=O | 5g | 600855396
1-Aminocyclopropane-1-carboxylic acid, N-BOC protected | Apollo Scientific | 88950-64-5 | MFCD00083257 | 201.222 | C9H15NO4 | 97.000 | CC(C)(C)OC(=O)NC1(CC1)C(O)=O | 5g | 600855396
Biotium Tyramides and Tyramide Signal Amplification Kits Fluorescence Microscopy Reactive CF Dyes Other Dyes Biotinylation Reagents TyraMax 560 580 1/EA
TyraMax Dyes are next-generation tyramide (TSA) dyes for spatial biology with colors from blue to near-IR named for their excitation/emission They are stable in amplification buffer with advantages in color selection brightness and photostability versus other TSA dyes 100X in DMSO 100 uL
Medchemexpress LLC Deucravacitinib | 1609392-27-9 | 99.9% | 425.46 | 200 MG
Deucravacitinib is a highly selective, orally bioavailable allosteric TYK2 inhibitor designed for the treatment of autoimmune diseases. It works by selectively binding to the TYK2 pseudokinase (JH2) domain, which blocks receptor-mediated Tyk2 activation by stabilizing its regulatory JH2 domain. This action inhibits IL-12/23 and type I IFN pathways. It is used for studying moderate to severe plaque psoriasis.
- Highly selective, orally bioavailable allosteric TYK2 inhibitor
- Designed for the treatment of autoimmune diseases
- Selectively binds to the TYK2 pseudokinase (JH2) domain
- Blocks receptor-mediated Tyk2 activation
- Inhibits IL-12/23 and type I IFN pathways
- Used for studying moderate to severe plaque psoriasis
- FDA's first de novo deuterium
Medchemexpress LLC SB225002 | 182498-32-4 | 99.9% | 352.14 | 200 MG
SB225002 | 182498-32-4 | 99.9% | 352.14 | 200 MG
Apexbio Technology LLC GNF-5837 1033769-28-6 200mg
GNF-5837 (CAS 1033769-28-6) is a potent and selective pan-Trk inhibitor exhibiting inhibitory activity against TrkA and TrkB with IC50 values of 8 nM and 12 nM respectively In cellular assays GNF-5837 suppresses proliferation in TRKA/NGF-expressing Ba/F3 and RIE cells with IC50 values of 0 042 M and 0 017 M respectively The compound has also been shown to inhibit c-Kit and PDGFR in select cell models In vivo GNF-5837 demonstrated dose-dependent tumor inhibition in xenograft mouse models derived from TRKA/NGF-expressing RIE cells Its oral bioavailability and specificity make it a valuable tool for investigating TRK signaling in oncogenic processes and other disease models No clinical evaluation has been reported to date
Apexbio Technology LLC Tebuconazole 107534-96-3 200mg
Tebuconazole (CAS 107534-96-3) is a small-molecule inhibitor targeting CYP51 a key enzyme in fungal sterol biosynthesis It modulates CYP51 activity to regulate sterol production within fungal cells Tebuconazole exerts its biological activity primarily through inhibition of CYP51 In cell-based assays tebuconazole demonstrates inhibitory activity with an IC50 value of 0 9 M against CaCYP51 from Candida albicans and 1 3 M against truncated human 60HsCYP51 Additionally in HepG2 cells tebuconazole induces lipid accumulation and oxidative stress and in mammary epithelial MAC-T cells it reduces proliferation and induces endoplasmic reticulum stress-mediated apoptosis Based on these pharmacological properties tebuconazole holds research potential in studies of fungal sterol biosynthesis cellular stress response pathways and apoptosis mechanisms
![Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000436072-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG
Guanidinoethyl sulfonate (Standard) is an analytical standard and an orally available, blood-brain permeable competitive inhibitor of taurine transporters. It acts as a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) and shows weak agonist/antagonist effects on GABAA receptors. It inhibits taurine transmembrane transport, blocks glycine-mediated chloride influx, and may regulate brain pH for neuroprotective effects, useful in studies of ischemic brain injury. It is applied in qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.
- Analytical standard for research
- Orally available and blood-brain permeable
- Inhibits taurine transporters
- Antagonizes glycine receptors
- Modulates GABAA receptors
- Blocks glycine-mediated chloride influx
- May offer neuroprotective effects
- Used in HPLC, GC, and MS applications
Apexbio Technology LLC Dp44mT 152095-12-0 200mg
Dp44mT (CAS 152095-12-0) is a small molecule iron chelator that selectively inhibits topoisomerase II a critical enzyme involved in chromosome segregation DNA replication and transcription In human breast cancer MDA-MB-231 cells Dp44mT exhibits a GI50 of approximately 100 nmol/L Experiments indicate that its cytotoxic effects are reduced in cells with diminished topoisomerase II expression underscoring target specificity Dp44mT treatment leads to the formation of covalent DNA-topoisomerase II complexes without affecting topoisomerase I or II These properties support its utility in studies on DNA damage enzymatic selectivity and mechanisms underlying cancer cell cytotoxicity
![Medchemexpress LLC Anthra[1,9-cd]pyrazol-6(2H)-one | 129-56-6 | 99.7% | 200 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233193.png-250.jpg)
Medchemexpress LLC Anthra[1,9-cd]pyrazol-6(2H)-one | 129-56-6 | 99.7% | 200 MG
SP600125 is a reversible, ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK1, JNK2, JNK3) used as a research reagent. Reported IC50 values are 40 nM for JNK1, 40 nM for JNK2, and 90 nM for JNK3. The compound has also been reported to inhibit ferroptosis and to induce conversion from autophagy to apoptosis in certain cancer cells.
- ATP-competitive inhibitor of JNK1, JNK2, and JNK3.
- IC50 values: 40 nM (JNK1), 40 nM (JNK2), 90 nM (JNK3).
- High purity (99.73%).
- Available as a 200 MG pack for research and analytical use.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
- Intended for research use only.
Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | MFCD00003544 | 96.09 | 10 G
1H-Imidazole-2-carbaldehyde is a biochemical reagent suitable for life science research as a biological material or organic compound. This compound acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor with potential applications in suppressing type-2 diabetes.
- Can be used as a biological material or organic compound for life science related research.
- Acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor.
- Has potential application to suppress type-2 diabetes.
- Used in the preparation of tridentate Schiff-base carboxylate-containing ligands by condensation reaction with amino acids.
- Involved in the study of imidazole-directed allylation of aldimines.
Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG
Methotrexate metabolite (DAMPA) is the primary active metabolite of methotrexate, supplied as an analytical standard for laboratory research, pharmacokinetic, and metabolism studies. It is intended for use as a reference standard in analytical assays and for investigation of methotrexate metabolism and clearance.
- Active metabolite of methotrexate used as an analytical standard.
- Suitable for pharmacokinetic and metabolism research.
- Molecular formula C15H15N7O2.
- Molecular weight 325.33 g/mol.
- Purity 98.4% (HPLC).
- Supplied as a solid for laboratory use.
- Not for human or veterinary use.